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Test Code 417 Homocysteine

Additional Codes

ALAB: HOMOCYS

PowerChart: Homocysteine Level

MA Cerner: Homocysteine

Test Method

One-Step Immunoassay; Abbott Architect

Specimen Requirement

0.5 mL serum or plasma is required.

Additional Specimen Collection Information

Collect blood in a lithium heparin green-top, EDTA purple-top or red-top tube. Serum and plasma gel tubes are acceptale. Place on wet ice immediately after collection. Separate the serum or plasma by centrifugation within 6 hours of collection. Transfer the serum or plasma to a separate tube, label appropriately and store on wet ice or refrigerate. Grossly hemolyzed specimens are not acceptable. Samples with >1+ lipemia must be cleared prior to analysis.

Performance

Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

STAT: Typically completed within 2 hours after the specimen arrives at the testing site.

Reference Values

Male: 5.9-16.0 mcmol/L

Female: 3.4-20.4 mcmol/L

CPT Code Information

83090 Chemistry: Homocysteine

 

BCBS requires a signed ABN. (Not covered for preventative care.)

Useful For

An aid for screening patients suspected of having an inherited disorder of methionine metabolism including:

  • Cystathionine beta-synthase deficiency (homocystinuria)
  • Methylenetetrahydrofolate reductase deficiency (MTHFR) and its thermolabile variants:
  • Methionine synthase deficiency
  • Cobalamin (Cbl) metabolism:
  • Combined methyl-Cbl and adenosyl-Cbl deficiencies: Cbl C2, Cbl D2, and Cbl F3 deficiencies
  • Methyl-Cbl specific deficiencies: Cbl D-Var1, Cbl E, and Cbl G deficiencies
  • Transcobalamin II deficiency:
  • Adenosylhomocysteinase (AHCY) deficiency
  • Glycine N-methyltransferase (GNMT) deficiency
  • Methionine adenosyltransferase (MAT) I/III deficiency

LOINC Code Information

13965-9 Homocysteine [Moles/Volume] In Serum Or Plasma