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Test Code 421 C-Reactive Protein, High Sensitivity

Important Note

Human anti-mouse antibodies (hama) may be present in samples from patients who have received immunotherapy or diagnostic procedures utilizing monoclonal antibodies or in individuals who have been regularly exposed to animals. Additionally, other heterophile antibodies, such as human anti-goat antibodies may be present in patient samples. Manufacturers formulate assays to minimize the effects of these antibodies; however careful evaluation of patient results must be done when patients are known to have such antibodies.

Additional Codes


PowerChart: C-Reactive Protein, High Sensitivity

MA Cerner: C-Reactive Protein, High Sensitivity.

Specimen Requirement

0.5 mL of serum or plasma is required.

Additional Specimen Collection Information

Collect blood in a lithium heparin, green-top or red-top tube. PST and SST (gel tubes) are acceptable. Serum or plasma should be separated from contact with the cells within 2 hours of collection. Specimens not centrifuged within 4 hours of collection may be rejected. Refrigerate the specimen if unable to assay within 8 hours of collection.

Useful For

Measuring of very low levels of CRP (i.e. “normal range” CRP) to stratify asymptomatic patients for cardiovascular risk only. These low levels are not predictive of other systemic inflammatory conditions usually associated with elevated CRP or sedimentation rate. 


Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

Expedite: Typically completed within 1.5 hours after the specimen arrives at the testing site.

STAT: Typically completed within 1 hour after the specimen arrives at the testing site.

CPT Code Information

86141 C-reactive protein; highly sensitive

LOINC Code Information

30522-7 C Reactive Protein [Mass/Volume] In Serum Or Plasma By High Sensitivity Method

Test Method

Near Infrared Particle Immunoassay Rate; Beckman DXC880i

Reference Values

Cardiovascular Risk Classification:

  • Low Risk: < 1.0 mg/L
  • Average Risk: 1.0-3.0 mg/L
  • High Risk: > 3.0 mg/L