Sign in →

Test Code 423 Cyclic Citrullinated Peptide Antibody (Anti CCP)

Additional Codes

ALAB: CCP

PowerChart: Cyclic Citrullinated Peptide Antibody IgG

MA Cerner: Cyclic Citrullinated Peptide Ab

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex

Specimen Requirement

Serum or plasma (EDTA or heparin) is required.

Additional Specimen Collection Information

Collect blood in a serum or lithium heparin plasma gel tube. Red-top serum, EDTA lavender-top or Heparin green-top are also acceptable. Serum or plasma must be separated from contact with the cells within 2 hours of collection. Specimens not centrifuged within 4 hours of collection may be rejected. Refrigerate the specimen if unable to assay within 8 hours of collection.

  • Volume: Minimum sample 500 mcL
  • Hemolysis: > 2+ not acceptable
  • Lipemia: > 3+ must be ultrafuged
  • Icterus: no interference
  • Heat-inactivated sera: Avoid
  • Storage: specimen is stable for up to 7 days refrigerated; freeze at -20oC for long term storage.
    Thoroughly mix thawed specimens; it is also recommended to centrifuge thawed specimens to remove gross particulate matter. Avoid multiple freeze-thaw cycles (up to 3 cycles are acceptable).

Performance

Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

STAT: Typically completed within 1 hour after the specimen arrives at the testing site.

Reference Values

< 3.0 U/mL = Negative
Anti-Cyclic Citrullinated Peptide (Anti-CCP), IgG antibodies are present in about 69-83 percent of patients with Rheumatoid Arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with low level positive results should be monitored and testing repeated.

CPT Code Information

86200 Diagnostic Immunology Testing: Cyclic citrullinated peptide (CCP), antibody

Useful For

Evaluating patients suspected of having rheumatoid arthritis (RA)

Differentiating RA from other connective tissue diseases that may present with arthritis

LOINC Code Information

32218-0 Cyclic Citrullinated Peptide Ab [Units/Volume] In Serum By Immunoassay