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Test Code HSTNI Troponin I, High Sensitivity

Important Note

1. Human anti-mouse antibodies (HAMA) may be present in samples from patients who have received immunotherapy utilizing monoclonal antibodies. Additionally, other heterophile antibodies such as human anti-goat antibodies may be present in patient samples. Manufacturers formulate assays to minimize the effects of these antibodies, however careful evaluation of patient results must be done when patients are known to have such antibodies..

Pretreatment of the specimen with Scantibodies HBT tubes may be performed for this assay after consultation with a Pathologist or Laboratory Director.

2. This testing method should not be used for patients taking asfotase alfa i.e. Strensiq.

3. Other potential interferences in the patient sample could be present and may cause erroneous results in immunoassays. Some examples that have been documented in literature include rheumatoid factor and fibrin. Carefully evaluate results if the sample is suspected of having these types of interferences. 

4. ALP levels above 400 U/L may cause false positive results.

5. Troponin results should be interpreted in light of the total clinical presentation of the patient, including symptoms, clinical history, data from additional tests, and other appropriate information. 

6. Troponin results differ between methods due to selection of standardization or traceability. Do not use results between troponin methods interchangeably. 

Additional Codes

ALAB: HSTNI

PowerChart: Troponin I High Sensitivity

MA Cerner: High Sensitivity Troponin I

Specimen Requirement

Lithium heparin plasma: 500 mcL (PST tubes are acceptable)

Additional Specimen Collection Information

Specimen storage and stability:

  • Specimens should be centrifuged within 2 hours of collection.
  • Plain Lithium Heparin specimens should be separated from the cells within 2 hours of collection.
  • If specimens cannot be assayed within 4 hours, store refrigerated at 2-8°C.
  • If specimens are to be stored longer than 48 hours they are stored frozen at -20°C for 180 days. Frozen specimens are thawed only once and at room temperature. Thawed samples must be centrifuged at 2200 rcf for 5 minutes prior to analysis.

     

Usefol For

Troponin I: Exclusion diagnosis of acute mycardial infarction

Performance

Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

STAT: Typically completed within 50 minutes after the specimen arrives at the testing site.

CPT Code Information

84484 Chemistry: Troponin, quantitative

LOINC Code Information

89579-7 Troponin I.cardiac [Mass/volume] in Serum or Plasma by High sensitivity method

Test Method

DxI: Two-Site Immunoenzymatic ("Sandwich") Assay; Beckman

Reference Values

Expected Results:

     Female: ≤ 14 ng/L

     Male: ≤ 20 ng/L

Patient Risk Assessment:

     Low Risk:

          0 hours < 5 ng/L AND Onset > 3 hours

          OR

          Female: 0 hours ≤ 14 ng/L; Male: 0 hours ≤ 20 ng/L AND a change in value after 1 hour <5              ng/L

     Moderate Risk:

          Female: 0 hours 15 – 100 ng/L; Male: 0 hours 21 – 100 ng/L

          AND

          A change in value after 1 hour ≥ 5 ng/L

     High Risk:

          >100 ng/L for Female or Male

          OR

          A change in value after 1 hour > 15 ng/L

(NOTE: Subsequent hsTnI lab draws should be performed hourly for assessment of the Patient in combination of HEART scores for Risk.)