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Test Code PSAHAMA PSA Total HAMA

Important Note

Manipulation of the prostate by rectal examination within 48 hours of specimen collection may result in elevated results. 5 alpha-reductase inhibitor drups may affect PSA levels.

Human anti-mouse antibodies (hama) may be present in samples from patients who have received immunotherapy or diagnostic procedures utilizing monoclonal antibodies or in individuals who have been regularly exposed to animals. Additionally, other heterophile antibodies, such as human anti-goat antibodies may be present in patient samples. Manufacturers formulate assays to minimize the effects of these antibodies; however careful evaluation of patient results must be done when patients are known to have such antibodies.

Additional Codes

ALAB: PSAHAMA

PowerChart: PSA Total w HAMA Treatment

MA Cerner: PSA Total HAMA

Specimen Requirement

0.5 mL serum required.

Additional Specimen Collection Information

Collect blood in a red-top tube. SST (serum gel tubes) are acceptable. Serum should be separated from contact with the cells within 2 hours of collection. Specimens not analyzed within 3 hours of collection must be refrigerated. If a specimen is to be stored longer than 24 hours it must be stored frozen at -20°C.

Test Method

Equimolar Two-Site Immunoenzymatic "Sandwich" Assay; Beckman

Performance

Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

Expedite: Typically completed within 1 hour after the specimen arrives at the testing site.

STAT: Typically completed within 30 minutes after the specimen arrives at the testing site.

Reference Values

Female: < 0.2 ng/mL

Male:

Age, Years

Total PSA ng/mL

Age, Years

 

Total PSA ng/mL

Age, Years

 

Total PSA ng/mL

≤ 40

0-2.0

54

0-3.2

68

0-4.9

41

0-2.1

55

0-3.3

69

0-5.1

42

0-2.2

56

0-3.4

70

0-5.3

43

0-2.3

57

0-3.5

71

0-5.4

44

0-2.3

58

0-3.6

72

0-5.6

45

0-2.4

59

0-3.7

73

0-5.8

46

0-2.5

60

0-3.8

74

0-6.0

47

0-2.6

61

0-4.0

75

0-6.2

48

0-2.6

62

0-4.1

76

0-6.4

49

0-2.7

63

0-4.2

77

0-6.6

50

0-2.8

64

0-4.4

78

0-6.8

51

0-2.9

65

0-4.5

79

0-7.0

52

0-3.0

66

0-4.6

≥ 80

0-7.2

53

0-3.1

67

0-4.8

 

 

Post prostatectomy: < 0.1 ng/mL

  • If the assay result of the HBT treated sample is the same as the original result, the original result is reported along with the comment “HAMA not detected.”.
  • If the assay result of the HBT treated sample is not the same as the original result, the original result is not reported. The comments “Unable to report" and "HAMA detected" are reported.

CPT Code Information

84153 Chemistry: Prostate specific antigen; total

G0103 for Medicare billing

NCD Frequency Limitations: Medicare covers a screening total PSA test one each year for men over 50 years of age.

 

BCBS requires a signed ABN. (For men < 50 yrs of age.)

Useful For

Monitoring patients with a history of prostate cancer as an early indicator of recurrence and response to treatment

Prostate cancer screening

LOINC Code Information

2857-1 Prostate specific Ag [Mass/volume] in Serum or Plasma

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