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Test Code TGAB Thyroglobulin Antibody II

Important Note

Human Anti-Mouse Antibodies (HAMA) may be present in samples from patients who have received immunotherapy utilizing monoclonal antibodies. Additionally, other heterophile antibodies such as human anti-goat antibodies may be present in patient samples. Manufacturers formulate assays to minimize the effects of these antibodies; however careful evaluation of patient results must be done when patients are known to have such antibodies.

Access Thyroglobulin Antibody II: potential of falsely decreased results when biotin concentrations are > 100 ng/mL.

Additional Codes

Powerchart: Thyroglobulin Antibody
MA Cerner: Thyroglobulin Antibody II

Specimen Requirement

0.5 mL of serum or heparin plasma

Additional Specimen Collection Information

Collection Instructions:
• Minimum volume: 500 mcL serum or heparin plasma
• Hemolysis: does not interfere with this assay
• Lipemia: does not interfere with this assay
• Icterus: does not interfere with this assay
• Storage: Can be stored at room temperature for up to 8 hours. If specimens are stored longer than 8 hours keep refrigerated (2-8C) until transport to the lab.

Reference Value

< 4.0 IU/mL


Testing is performed Monday through Sunday.
Routine: Typically completed within 4 hours after the specimen arrives at the testing site.
STAT: Typically completed within 1 hour after the specimen arrives at the testing site.

CPT Code Information


Test Method

Two-Site Immunoassay (Beckman Coulter)

Useful For

Thyroglobulin autoantibodies (TgAb) are often present in patients with autoimmune thyroid disease. Approximately 10% of healthy individuals have TgAb at measureable levels. TgAb can be detected in 30% of patients with Graves’ disease and in 85% of patients with Hashimoto’s thyroiditis. However, elevated levels of autoantibodies to thyroid peroxidase (TPO autoantibodies) occur more frequently than high TgAb levels in these diseases.
Sensitive TgAb methods are needed to identify patient sera that contain thyroglobulin autoantibodies that may interfere with serum thyroglobulin measurements.