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Test Code ZIKA Zika Virus Antibody Testing, Serum

Important Note

All specimens are submitted to the Hygienic Laboratory with a completed Viral and Bacterial PCR and DFA Test Request form and CDC specimen submission form CDC 50-34.
Additional information about Zika Virus is available online at the CDC (Center for Disease Control and PAHO (Pan American Health Organization) websites.

Additional Codes


PowerChart: Zika Virus Antibody 

MA Cerner: Zika Virus Testing, Blood

Specimen Requirement

1 mL serum is required.

Additional Specimen Collection Information

Send at least 1.0 mL serum specimen cold on ice packs or frozen.
Note: Samples that are to be sent frozen should be frozen as immediately as possible after collection.
Complete the Viral and Bacterial PCR and DFA Test Request form. If not already listed, indicate the specimen type on the “Other” line in the Specimen Information section. Write in Zika testing under the tests requested section and the recommended tests to be performed.

Complete the pre-populated CDC Specimen Submission Form CDC 50-34 to send along with the specimen(s).

  • A specimen should be triple packaged as a Category B Biological Substance.
  • Provide the date of illness onset, dates of specimen collection, specimen type, description of clinical illness, travel history, flavivirus vaccination history, and contact information for the submitter. Testing primarily will be performed on serum or CSF.

Reference Value


Useful For

Zika virus testing should be considered for patients with acute fever, rash, myalgia, or arthralgia who have traveled within the previous two weeks to an area with ongoing transmission of those viruses or are living in an area with ongoing transmission.
CDC recommends serologic testing for asymptomatic pregnant women with a history of travel (2 to 12 weeks post travel) to areas with local transmission of Zika virus or who are living in an area with ongoing transmission.


Test turn-around time is expected to be within 7 days. There may be delays if confirmatory testing is required.
The specific tests performed will depend on the timing of the specimens relative to illness onset and clinical information as outlined in the testing algorithm.

CPT Code Information

87798 x 2  Infectious agent detection by nucleic acid (DNA or RNA), not otherwise specified; direct probe technique, each organism (Chikungunya virus, Dengue virus)  and

87662  Infectious agent detection by nucleic acid (DNA or RNA), Zika virus, amplified probe technique

LOINC Code Information

80824-6 Zika virus IgM Ab [Presence] in Serum by Immunoassay

79190-5 Zika virus RNA [Presence] in Unspecified specimen by Probe and target amplification method

Test Method

Real-Time Reverse Transcription Polymerase Chain Reaction (PCR)/DNA Probe Hybridization
Antibody Capture Enzyme-Linked Immunosorbent Assay (MAC-ELISA)