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Test Code 001 CBC with Differential

Additional Codes

ALAB: CBC

PowerChart: CBC with Differential

MA Cerner: Complete Blood Count

Test Method

Sysmex XN and XS Systems:

  • WBC:  Flow cytometry
  • RBC:  Impedance counting
  • Platelet Count: Impedance counting
  • Platelet F Count: Flow cytometry fluorescence count (performed when appropriate)
  • HGB:  Converted to SLS-hemoglobin and read photometrically.
  • MCV:  The average volume of individual erythrocytes derived from the RBC histogram.
  • RDW:  The size distribution spread of the erythrocytes population derived from the RBC histogram.
  • MPV:  The average volume of individual platelets derived from the PLT histogram.
  • HCT: Measured as a ratio of the total RBC volume to whole blood using cumulative pulse height detection.
  • MCH, MCHC:  Calculated parameters.
    MCH: Weight of HGB  in the average RBC. MCH = HGB ÷ RBC x 10
    MCHC: Average weight of HGB in a measured dilution. MCHC = HGB ÷ HCT x 100
  • WBC Differential: The instrument makes 3 measurements (volume, conductivity and scatter) as each cell passes through the flow cell. The low frequency impedance measurement defines cell volume. The high frequency conductivity measurement indicates the internal conductivity. The light scatter measurement indicates the structure and shape. An algorithm is applied to determine different cell populations.
  • Abs Neutrophils, Abs Lymphocytes, Abs Monocytes, Abs Eosinophils, Abs Basophils:
    Calculated Parameters [Total WBC x (%Diff Analyte Result/100)] = Absolute Diff Analyte Count

Specimen Requirement

EDTA whole blood is required.

Additional Specimen Collection Information

Whole blood collected in EDTA purple-top tube. The tube must be at least one quarter full to be acceptable for testing.

Capillary specimen collected in EDTA microtube. The  tube must contain at least 375 mcL (bottom line) to be acceptable for testing.

The stability for all CBC/diff parameters including reticulocyte counts is 24 hours at room temperature, up to 48 hours at 2-8°C.

Performance

Testing is performed Monday through Sunday.

Routine orders: Typically completed within 4 hours after the specimen arrives at the testing site.

Expedite orders: Typically completed within 1 hour after the specimen arrives at the testing site.

STAT orders: Typically completed within 30 minutes after the specimen arrives at the testing site.

Reference Values

WBC:

0-1 Year, Male and Female: 6.0-17.5 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

1-2 Years, Male and Female: 6.0-17.0 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

2-4 Years, Male and Female: 5.5-15.5 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

4-6 Years, Male and Female: 5.0-14.5 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

6-8 Years, Male and Female: 4.5-13.5 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

8-10 Years, Male and Female: 4.5-13.5 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

10-16 Years, Male and Female: 4.5-13.0 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

Adult Male and Female: 3.7-11.0 thou/mcL

  • Critical Value:
    • High: > 50.0
    • Low: < 1.0

RBC:

0-15 days Male and Female: 3.9-5.9 mil/mcL

15 days-1 month Male and Female: 3.3-5.3 mil/mcL

1-4 months Male and Female: 3.5-5.1 mil/mcL

4-6 months Male and Female: 3.9-5.5 mil/mcL

6-9 months Male and Female: 4.0-5.3 mil/mcL

9 months-1 year Male and Female: 4.1-5.3 mil/mcL

1-3 years Male and Female: 3.8-4.8 mil/mcL

3-6 years Male and Female: 3.7-4.9 mil/mcL

6-9 years Male and Female: 3.8-4.9 mil/mcL

9-12 years Male and Female: 3.9-5.1 mil/mcL

12-15 years:

Male: 4.1-5.2 mil/mcL

Female: 3.8-5.0 mil/mcL

15-18 years:

Male: 4.2-5.6 mil/mcL

Female: 3.9-5.1 mil/mcL

18-45 years:

Male: 4.3-5.7 mil/mcL

Female: 3.8-5.1 mil/mcL

45-65 years:

Male: 4.2-5.6 mil/mcL

Female: 3.8-5.3 mil/mcL

≥ 65 years:

Male: 3.8-5.8 mil/mcL

Female: 3.8-5.2 mil/mcL

Hemoglobin:

0-15 days Male and Female: 13.4-19.8 g/dL

  • Critical Value:
    • High: >22.0
    • Low: <12.5

15 days-1 month Male and Female: 10.7-17.1 g/dL

  • Critical Value:
    • High: >22.0
    • Low: <8.0

1-2 months Male and Female: 9.4-13.0 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

2-4 months Male and Female: 10.3-14.1 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

4-6 months Male and Female: 11.1-14.1 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

6 months-5 years Male and Female: 11.0-14.0 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

5-9 years Male and Female: 11.5-14.5 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

9-12 years Male and Female: 12.0-15.0 g/dL

  • Critical Value:
    • High: >17.0
    • Low: <8.0

12-15 years

 Male: 12.0-16.0 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

Female: 11.5-15.0 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

15-18 years

Male: 11.7-16.6 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

Female: 11.7-15.3 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

18-45 years

Male: 13.2-17.3 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

Female: 11.7-15.5 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

45-65 years

Male: 13.1-17.2 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

Female: 11.7-16.0 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

≥ 65 years:

Male: 12.6-17.4 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0

Female: 11.7-16.1 g/dL

  • Critical Value:
    High: >20.0
    Low: <7.0 

Hematocrit:

0-15 days Male and Female: 41-65%

15 days-1 month Male and Female: 33-55%

1-2 months Male and Female: 28-42%

2-4 months Male and Female: 32-44%

4-6 months Male and Female: 31-41%

6-9 months Male and Female: 32-40%

9 months-1 year Male and Female: 33-41%

1-3 years Male and Female: 32-40%

3-6 years Male and Female: 32-42%

6-9 years Male and Female: 33-41%

9-12 years Male and Female: 34-43%

12-15 years:

Male: 35-45%

Female: 34-44%

15-18 years:

Male: 37-48%

Female: 34-44%

18-45 years:

Male: 39-49%

Female: 35-45%

45-65 years:

Male: 39-49%

Female: 35-47%

≥ 65 years:

Male: 37-51%

Female: 35-47%

MCV: 80-100 fL

MCH: 26 - 34 pg

MCHC: 32 - 37 g/dL

RDW: 12.1 – 15.2%

Platelet Count: 150 - 400 x thou/mcL

  • Critical Value:
    • High: >1000 thou/mcL
    • Low: <30 thou/mcL

Oncology: <10 thou/mcL

MPV: 9.4-12.4 FL

Neutrophils: 42.0-74.0%

Lymphocytes: 18.0-44.0%

Monocytes: 5.0-13.0%

Eosinophils: 0.0-8.0%

Basophils: 0.0-1.0%

Absolute Neutrophils: 1.6-6.1 thou/mcL

  • Critical Value: Low: < 0.5 thou/mcL

Absolute Monocytes: 0.2-0.8 thou/mcL

Absolute Eosinophils: 0.0-0.5 thou/mcL

Absolute Basophils: 0.0-0.1 thou/mcL

Absolute IG: 0.0-0.1 thou/mcL

IPF: 1.0-7.0%

CPT Code Information

85025 Blood Counts: complete (CBC), automated (Hgb, Hct, RBC, WBC and platelet count) and automated differential WBC count

85027 Blood Counts: complete (CBC), automated (Hgb, Hct, RBC, WBC and platelet count), when appropriate

85007 Blood Counts: blood smear, microscopic examination with manual differential count, when appropriate

 

BCBS requires a signed ABN. (Not covered for preventative care.)

Useful For

Screening tool to confirm a hematologic disorder.

Establish or rule out a diagnosis.

Detect an unsuspected hematologic disorder.

Monitor effects of radiation or chemotherapy.

These counts are used as clinical guides in the diagnosis and/or monitoring of many diseases.

LOINC Code Information

57021-8 CBC with Auto Differential Panel-Blood

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