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HelpTest Code CENTB Centromere B Antibody
Additional Codes
ALAB: CENTB
Powerchart: Centromere Antibody
MA Cerner: Centromere Ab, IgG
Test Method
Multiplex Flow Immunoassay; BioRad BioPlex.
Specimen Requirement
0.5 mL of serum. Gel tubes are preferred.
Additional Specimen Collection Information
Collection Instructions:
- Minimum volume: 500 mcL
- Hemolysis: Samples with hemolysis >2+ are not acceptable
- Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
- Icterus: No interference
- Storage: Stable for up to 7 days at 2-8°C.
Performance
Testing is performed Monday through Friday.
Reference Value
Centromere B Antibody: Negative (<1 AI) Reported as an antibody index.
CPT Code Information
83516-Centromere Antibody.
Useful For
Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis including skin involvement, Raynaud phenomenon, and arthralgias
Aiding in the diagnosis of calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome
In various reported clinical studies, centromere antibodies occur in 50% to 96% of patients with calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome.
A positive test for centromere antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome by several years.