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HelpTest Code CHROM Chromatin Antibody
Additional Codes
ALAB: CHROM
Powerchart: Chromatin (Nucleosomal) Antibody
MA Cerner: Chromatin (Nucleosomal) Antibody
Test Method
Multiplex Flow Immunoassay; BioRad BioPlex
Specimen Requirement
0.5 mL of serum. Gel tubes are preferred.
Additional Specimen Collection Information
Collection Instructions:
- Minimum volume: 500 mcL
- Hemolysis: Samples with hemolysis >2+ are not acceptable
- Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
- Icterus: No interference
- Storage: Stable for up to 7 days at 2-8°C.
Performance
Testing is performed Monday through Friday.
Reference Value
Chromatin Antibody: Negative (<1 AI) Reported as an antibody index.
CPT Code Information
86235-Chromatin Antibody
Useful For
Anti-Chromatin is a diagnostic marker for SLE with a reported sensitivity of up to 86% and is also encountered in some patients with Mixed Connective Tissue Disease. Anti-Chromatin antibodies are more often positive in SLE patients than anti-dsDNA using the Bioplex ANA Screen. Anti-Chromatin antibodies may also be detected in patients with Drug Induced Lupus.