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Test Code DSDNA Double Stranded DNA Antibody

Important Note

A positive result may occur in patients with diseases other than SLE. A negative result does not exclude a diagnosis of SLE.

Additional Codes


Powerchart: DNA Antibody Double Strand

MA Cerner: DNA Double-Stranded (dsDNA) Ab, IgG

Specimen Requirement

0.5 mL of serum. Gel tubes are preferred.

Additional Specimen Collection Information

Collection Instructions:

  • Minimum volume: 500 mcL
  • Hemolysis: Samples with hemolysis >2+ are not acceptable
  • Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
  • Icterus: No interference
  • Storage: Stable for up to 7 days at 2-8°C.

Reference Value

dsDNA Antibody: Negative (≤4 IU/mL)

Useful For

Evaluating patients with signs and symptoms consistent with systemic lupus erythematosus (SLE).

Monitoring patients with documented SLE for flares in disease activity.
A positive test result for double-stranded DNA (dsDNA) antibodies is consistent with the diagnosis of systemic lupus erythematosus.



Testing is performed Monday through Friday.

CPT Code Information

86225-dsDNA Antibody

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex