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Test Code EBVP Epstein-Barr Virus Antibody Profile

Additional Codes

Powerchart: Epstein Barr Virus Panel
MA Cerner: Epstein-Barr Virus (EBV) Antibody Profile

Specimen Requirement

1 mL serum (serum gel tube preferred) is required.

Additional Specimen Collection Information

Collect blood in a serum gel tube. Red-top serum is also acceptable. Serum should be separated from contact with the cells within 2 hours of collection. Refrigerate the specimen if unable to assay within 8 hours of collection.

  • Minimum volume: 500 mcL
  • Hemolysis: > 2+ not acceptable
  • Lipemia: > 3+ must be ultrafuged
  • Icterus: no significant interference
  • Storage: specimen is stable for up to 7 days refrigerated; freeze at -20oC for long term storage.
    Thoroughly mix thawed specimens; it is also recommended to centrifuge thawed specimens to remove gross particulate matter. Avoid multiple freeze-thaw cycles (up to 3 cycles are acceptable).

Reference Value

EBV Capsid Antigen IgG Antibody: Negative
EBV Capsid Antigen IgM Antibody: Negative
EBV Nuclear Antigen IgG Antibody: Negative


                       Interpretation of Serologic Results: Diagnostic Algorithm


Seronegative (-) (-) (-) (-)
Early Acute (-) (±) (±) (+)
Late Acute (-) (+) (+) (+)
Past Infection (+) (±) (+) (-)
Seropositive (+) (±) (+) (-)


Useful For

Diagnosing infectious mononucleosis when a mononucleosis screening procedure is negative and infectious mononucleosis or a complication of Epstein-Barr virus infection is suspected.


Testing is performed Monday through Sunday.
Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

CPT Code Information

86664  Antibody, Epstein-Barr Virus, nuclear antigen (EBNA)
86665 x 2  Antibody, Epstein-Barr Virus, viral capsid (VCA)

LOINC Code Information

30339-6  Epstein Barr virus capsid IgG Ab [Presence] in Serum
30340-4  Epstein Barr vrus capsid IgM Ab [Presence] in Serum
22296-8  Epstein Barr virus nuclear Ab [Presence] in Serum

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex