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Test Code RIBOP Ribosomal P Antibody

Important Note

This test should not be relied upon to establish the diagnosis or to rule out the diagnosis in a patient with signs and symptoms compatible with LE.

Additional Codes


Powerchart: Ribosomal P Protein IgG Antibody

MA Cerner: Ribosome P Ab, IgG

Specimen Requirement

0.5 mL of serum. Gel tubes are preferred.

Additional Specimen Collection Information

Collection Instructions:

  • Minimum volume: 500 mcL
  • Hemolysis: Samples with hemolysis >2+ are not acceptable
  • Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
  • Icterus: No interference
  • Storage: Stable for up to 7 days at 2-8°C.

Reference Value

Ribosomal P Antibody: Negative (<1 AI) Reported as an antibody index.

Useful For

As an adjunct in the evaluation of patients with lupus erythematosus (LE) 

Aids in the differential diagnosis of neuropsychiatric symptoms in patients with LE

Since patients with LE may manifest signs and symptoms of CNS diseases including neuropsychiatric symptoms, the presence of antibodies to ribosome P protein may be useful in the differential diagnosis of such patients. Other causes of CNS symptoms in patients with LE include thrombosis with or without antibodies to phospholipid antigens and iatrogenic effects from treatment with corticosteroid drugs.
A positive result is consistent with the diagnosis of lupus erythematosus, and may indicate the presence of central nervous system involvement.


Testing is performed Monday through Friday.

CPT Code Information

83516-Ribosomal P Antibody

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex