Sign in →

Test Code RNP RNP Antibody

Important Note

Testing for RNP antibodies is not useful in patients without demonstrable antinuclear antibodies.

Additional Codes


Powerchart: Anti RNP Antibody

MA Cerner: RNP Ab, IgG

Specimen Requirement

0.5 mL of serum. Gel tubes are preferred.

Additional Specimen Collection Information

Collection Instructions:

  • Minimum volume: 500 mcL
  • Hemolysis: Samples with hemolysis >2+ are not acceptable
  • Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
  • Icterus: No interference
  • Storage: Stable for up to 7 days at 2-8°C.

Reference Value

RNP Antibody: Negative (<1 AI) Reported as an antibody index.

Useful For

Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive
A positive result for RNP antibodies is consistent with a connective tissue disease. Although strongly associated with connective tissue diseases, RNP antibodies are not considered a "marker" for any particular disease except in the following situation: when found in isolation (ie, dsDNA antibodies and Sm antibodies are not detectable), a positive result for RNP antibodies is consistent with the diagnosis of mixed connective tissue disease.


Testing is performed Monday through Friday.

CPT Code Information

86235-RNP Antibody

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex