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Test Code SM Sm Antibody

Important Note

Testing for Sm antibodies is not useful in patients without demonstrable antinuclear antibodies.

Additional Codes


Powerchart: Anti-Smith Antibody

MA Cerner: Sm Ab, IgG

Specimen Requirement

0.5 mL of serum. Gel tubes are preferred.

Additional Specimen Collection Information

Collection Instructions:

  • Minimum volume: 500 mcL
  • Hemolysis: Samples with hemolysis >2+ are not acceptable
  • Lipemia: Samples with lipemia >3+ must be ultracentrifuged prior to analysis
  • Icterus: No interference
  • Storage: Stable for up to 7 days at 2-8°C.

Reference Value

Sm Antibody: Negative (<1 AI) Reported as an antibody index.

Useful For

Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive
A positive result for anti-Sm antibodies is consistent with a diagnosis of lupus erythematosus.



Testing is performed Monday through Friday.

CPT Code Information

86235-Sm Antibody

Test Method

Multiplex Flow Immunoassay; BioRad BioPlex